Glutathione Peroxidase-3 and Its Impact on Health in the Elderly
Author Information
Author(s): Alexander Jan, Aaseth Jan Olav, Schomburg Lutz, Chillon Thilo Samson, Larsson Anders, Alehagen Urban
Primary Institution: Norwegian Institute of Public Health
Hypothesis
Low-selenium status is associated with impaired renal function and increased mortality in elderly individuals.
Conclusion
Supplementation with selenium and coenzyme Q10 improved renal function and increased glutathione peroxidase-3 levels in elderly individuals.
Supporting Evidence
- Low selenium status was linked to impaired kidney function.
- Supplementation improved kidney function by approximately 23%.
- Low GPx3 levels were associated with double the risk of mortality.
Takeaway
Elderly people with low selenium levels may have kidney problems and a higher chance of dying, but taking selenium and coenzyme Q10 can help improve their health.
Methodology
The study involved a randomized controlled trial with 383 participants, measuring serum glutathione peroxidase-3 and its relationship with selenium levels, renal function, and mortality.
Potential Biases
The study was funded by organizations with no role in the design or analysis, reducing potential bias.
Limitations
The study's limited population size may affect the reliability of the results, and it only included one treatment group.
Participant Demographics
Elderly individuals aged 69-88 from a rural municipality in Southeast Sweden.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 97–108 µg/L
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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