Human melanoma cells inhibit the earliest differentiation steps of human Langerhans cell precursors but failed to affect the functional maturation of epidermal Langerhans cells
2001
Melanoma Cells and Langerhans Cell Differentiation
publication
Author Information
Author(s): Berthier-Vergnes O, Gaucherand M, Péguet-Navarro J, Plouet J, Pageaux J-F, Schmitt D, Staquet M-J
Primary Institution: INSERM U 346, Hôpital Edouard Herriot, Lyon, France
Hypothesis
Do melanoma cells affect the differentiation and maturation of Langerhans cells?
Conclusion
Melanoma cells inhibit the early differentiation of Langerhans cell precursors but do not affect the maturation of existing Langerhans cells.
Supporting Evidence
- Melanoma cells diverted the differentiation of CD34+ cells towards a dominant CD14+ population.
- Co-culture of fresh epidermal Langerhans cells with melanoma cells did not affect their phenotype and function.
Takeaway
Melanoma cells can stop certain immune cells from developing, but they don't change the ones that are already there.
Methodology
CD34+ cord blood progenitors were co-cultured with melanoma cells to assess differentiation and maturation.
Participant Demographics
CD34+ cord blood progenitors were used in the study.
Digital Object Identifier (DOI)
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