Blood Biomarkers and Postoperative Delirium in Older Adults
Author Information
Author(s): Lee Hyangkyu, Cho Hyeonmi, Choi Jeongeun, Park Hyunki
Primary Institution: Yonsei University
Hypothesis
The study evaluates the associations of neurological biomarkers with the incidence, severity, duration, and subtype of postoperative delirium.
Conclusion
Blood biomarkers can help predict the severity, duration, and subtype of postoperative delirium in older adults.
Supporting Evidence
- Each 1 standard deviation increase in NfL was associated with a 1.51 increase in the peak DRS-R-98 severity score.
- Each 1 standard deviation rise in GFAP was associated with an odds ratio of 2.08 for delirium duration of 4 days or more.
- Each 1 standard deviation rise in NfL was associated with an odds ratio of 2.35 for delirium duration of 4 days or more.
- The odds ratio for the hypoactive subtype of delirium increased by 1 standard deviation in Aβ42.
Takeaway
Doctors can use blood tests to see how bad and how long confusion after surgery might last in older patients.
Methodology
Patients over 70 years old who had spine surgery were matched for a study comparing those with and without postoperative delirium, measuring various neurological biomarkers from blood samples.
Participant Demographics
Patients over 70 years old.
Statistical Information
Confidence Interval
95% confidence interval: 0.07 to 2.95 for severity score; 95% confidence interval: 1.15 to 3.74 for GFAP; 95% confidence interval: 1.13 to 4.92 for NfL; 95% CI: 1.28 to 6.66 for hypoactive subtype.
Digital Object Identifier (DOI)
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