Effect of Acipimox on Plasma Lipids and Glucose/Insulin in Pregnant Rats
Author Information
Author(s): I. Sanchez-Vera, B. Bonet, M. Viana, E. Herrera, A. Indart
Primary Institution: Facultad de Ciencias Experimentales y de la Salud, Universidad San Pablo-CEU, Madrid, Spain
Hypothesis
How does a reduction in maternal hypertriglyceridemia during late pregnancy affect glucose/insulin relationships?
Conclusion
Acipimox treatment during late pregnancy inhibited lipolysis and decreased fetal weight, but did not affect peripheral insulin resistance.
Supporting Evidence
- Acipimox treatment reduced plasma triglycerides, free fatty acids, and glycerol in pregnant rats.
- Fetal body weight was lower in pregnant rats treated with acipimox compared to controls.
- Insulin release was greater in pregnant rats treated with acipimox after glucose administration.
Takeaway
This study looked at how a medicine called acipimox affects pregnant rats. It found that while it lowered certain fats in the blood, it didn't help with insulin resistance.
Methodology
Pregnant and virgin rats were treated with acipimox or distilled water, and various blood parameters were measured over time.
Limitations
The study was conducted on rats, which may not fully represent human physiology.
Participant Demographics
Female virgin Wistar rats, weighing 190 to 220 g.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website