Production of camptothecin in cultures of Chonemorpha grandiflora
2010
Production of Camptothecin in Chonemorpha grandiflora
publication
Evidence: moderate
Author Information
Author(s): Kulkarni A. V., Patwardhan A. A., Lele U., Malpathak N. P.
Primary Institution: University of Pune
Hypothesis
Can Chonemorpha grandiflora produce camptothecin in callus cultures?
Conclusion
Chonemorpha grandiflora could be a new promising alternative source of camptothecin.
Supporting Evidence
- Camptothecin was detected in ethanolic extracts of stem with bark and callus cultures.
- The camptothecin content was 0.013 mg/g in stem with bark and 0.003 mg/g in callus.
- This is the first report on in vivo and in vitro production of camptothecin in C. grandiflora.
Takeaway
This study found that a plant called Chonemorpha grandiflora can make a special medicine called camptothecin, which is used to fight cancer.
Methodology
Callus cultures were raised on Murashige and Skoog’s medium and analyzed using TLC, HPTLC, and HPLC.
Limitations
The amount of camptothecin produced is low compared to other known sources.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website