Effects of Ulinastatin and Docataxel on Breast Tumor Growth
Author Information
Author(s): Zhao Xiaoliang, Sun Xin, Gao Feng, Luo Jie, Sun Zhijun
Primary Institution: Second Affiliated Hospital of Chongqing Medical University
Hypothesis
This study investigated the effects of Ulinastatin (UTI) and docataxel (Taxotere, TAX) on tumor growth and expression of interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-α (TNF-α) in breast cancer.
Conclusion
Both UTI and TAX inhibited the growth of MDA-MB-231 breast carcinoma cells, with UTI enhancing the inhibitory effect of TAX.
Supporting Evidence
- UTI, TAX, and UTI+TAX inhibited the growth of MDA-MB-231 cells in vitro and tumors in vivo.
- The combination of UTI and TAX produced the strongest inhibitory effect on tumor growth.
- Treatment with UTI+TAX resulted in the greatest decrease in IL-6, IL-8, and TNF-α expression.
Takeaway
This study found that two drugs, Ulinastatin and Docataxel, can help stop breast cancer cells from growing and make them die more easily.
Methodology
MDA-MB-231 human breast carcinoma cells were cultured and injected into nude mice to establish breast tumor xenografts, followed by treatment with UTI, TAX, and UTI+TAX.
Limitations
One mouse in the control group died, and the study was limited to a specific cell line and mouse model.
Participant Demographics
Fifty female BALB/c-nu/nu nude mice, 5 weeks old.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website