Elevations in D-dimer levels in patients with Plasmodium infections: a systematic review and meta-analysis

2025

D-dimer Levels in Malaria Patients

Sample size: 1418 publication 10 minutes Evidence: moderate

Author Information

Author(s): Sukati Suriyan, Kotepui Kwuntida Uthaisar, Masangkay Frederick Ramirez, Tseng Ching-Ping, Mahittikorn Aongart, Anabire Nsoh Godwin, Wilairatana Polrat, Wangdi Kinley, Majima Hideyuki J, Suwannatrai Apiporn Thinkhamrop, Klangbud Wiyada Kwanhian, Mala Wanida, Rattanatham Rujikorn, Kotepui Manas

Primary Institution: Walailak University

Hypothesis

This systematic review and meta-analysis aimed to synthesize evidence of D-dimer alteration in people with malaria, including variations in disease severity.

Conclusion

Malaria patients have significantly higher D-dimer levels compared to non-malarial individuals, but no significant difference in D-dimer levels was observed between severe and uncomplicated malaria cases.

Supporting Evidence

Patients with Plasmodium infections had higher D-dimer levels compared to non-malarial individuals.
A meta-analysis revealed a significant elevation of D-dimer in patients with malaria.
No significant difference in D-dimer levels was found between severe and uncomplicated malaria cases.
The study included 24 studies with a total of 1,418 participants.
D-dimer levels were assessed using various assays and blood sample types.

Takeaway

People with malaria have more D-dimer in their blood, which can help doctors understand how sick they are, but it doesn't always show if someone has a more serious case.

Methodology

A systematic review and meta-analysis were conducted, including searches in multiple databases to identify studies reporting D-dimer levels in malaria patients.