Nephrotoxicity in Wilms' Tumour Survivors
Author Information
Author(s): Bailey S, Roberts A, Brock C, Price L, Craft A W, Kilkarni R, Lee R E J, Skillen A W, Skinner R
Primary Institution: Department of Child Health, University of Newcastle upon Tyne
Hypothesis
What is the prevalence and nature of renal toxicity in survivors of Wilms' tumour?
Conclusion
The study found that treatment for Wilms' tumour rarely causes long-term renal impairment in most patients.
Supporting Evidence
- The median glomerular filtration rate was 100 ml/min/1.73m².
- Nine patients had a GFR below the reference range for healthy individuals.
- Subclinical measures of tubular toxicity were abnormal in only four patients.
- Compensatory renal hypertrophy was seen in all but two patients.
Takeaway
This study looked at kids who survived a type of kidney cancer and found that their treatment usually doesn't hurt their kidneys in the long run.
Methodology
The study measured glomerular filtration rate and tubular function in 40 survivors of Wilms' tumour.
Potential Biases
Potential bias due to the exclusion of patients who had moved or declined participation.
Limitations
The study had a small sample size and some patients were not included due to various reasons.
Participant Demographics
40 patients (24 female) with a median age of 4.3 years at diagnosis.
Statistical Information
P-Value
0.03
Statistical Significance
p=0.03
Digital Object Identifier (DOI)
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