Effect of Dentition Type on Microbial Load Reduction by Antimicrobial Photodynamic Therapy
Author Information
Author(s): Baghani Zahra MScD, Karrabi Malihe MScD, Assarzadeh Hossein MScD
Primary Institution: Sabzevar University of Medical Sciences
Hypothesis
Can the type of dentition (primary or permanent) serve as a determinant of the efficacy of antimicrobial photodynamic therapy (aPDT) for reducing microbial load in deep caries?
Conclusion
aPDT is effective in reducing microbial load in permanent teeth but not significantly in primary teeth.
Supporting Evidence
- aPDT significantly reduced total bacterial count in permanent teeth.
- aPDT had a significant effect on S. mutans count in primary teeth.
- High heterogeneity was observed in studies on primary teeth.
Takeaway
This study found that a special light treatment can help kill bacteria in deep cavities, but it works better in adult teeth than in children's teeth.
Methodology
A systematic review and meta-analysis of 7 randomized clinical trials comparing bacterial counts before and after aPDT in primary and permanent teeth.
Potential Biases
Some studies had concerns regarding randomization and blinding.
Limitations
The study did not account for age-related changes in dentinal tubules and had variations in treatment protocols across studies.
Participant Demographics
Healthy children and adults with deep caries in primary or permanent teeth.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI: (0.31, 0.96)
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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