Dual-Loaded Niosomal Gel for Eye Medicine
Author Information
Author(s): Gugleva Viliana, Mihaylova Rositsa, Kamenova Katya, Zheleva-Dimitrova Dimitrina, Stefanova Denitsa, Tzankova Virginia, Zaharieva Maya Margaritova, Najdenski Hristo, Forys Aleksander, Trzebicka Barbara, Petrov Petar D., Momekova Denitsa
Primary Institution: Medical University of Varna
Hypothesis
Can a dual-loaded niosomal gel improve drug delivery for eye treatments?
Conclusion
The developed niosomal in situ gel is a promising platform for delivering CBD and EGCG to the eye.
Supporting Evidence
- The niosomal gel showed superior inhibition of MRSA adhesion compared to untreated controls.
- High entrapment efficiency for both CBD and EGCG was achieved.
- The gel exhibited suitable rheological characteristics for ocular application.
- Dual loading of CBD and EGCG enhanced their protective properties against oxidative stress.
Takeaway
This study created a special gel that can deliver medicine to the eye better than regular eye drops.
Methodology
The study involved preparing dual-loaded niosomes using the thin film hydration method, followed by physicochemical evaluation and incorporation into an in situ gel.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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