Diet, smoking and lung cancer: a case-control study of 1000 cases and 1500 controls in South-West England
2001

Diet, Smoking, and Lung Cancer Study

Sample size: 2468 publication Evidence: moderate

Author Information

Author(s): Darby S, Whitley E, Doll R, Key T, Silcocks P

Primary Institution: ICRF/MRC/BHF Clinical Trial Service Unit & Epidemiological Studies Unit, Radcliffe Infirmary, Oxford

Hypothesis

What is the relationship between diet and lung cancer risk?

Conclusion

The study found significant associations between certain dietary factors and lung cancer risk, suggesting at least one unidentified factor is causally related to lung cancer.

Supporting Evidence

  • Significant associations were found for 13 dietary variables related to lung cancer risk.
  • Five dietary factors remained significantly associated with lung cancer after adjusting for smoking.

Takeaway

Eating certain foods might affect your chances of getting lung cancer, and there could be something else we don't know about that also plays a role.

Methodology

Case-control study with personal interviews about smoking habits and dietary intake.

Potential Biases

Potential biases in self-reported dietary intake and smoking habits.

Limitations

Some associations may not represent biological effects and could be influenced by confounding factors.

Participant Demographics

Participants included 982 cases of lung cancer and 1486 population controls from south-west England.

Statistical Information

Statistical Significance

p<0.01

Digital Object Identifier (DOI)

10.1054/bjoc.2000.1668

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