Linkage Analysis of Alcoholism and P300 Amplitude
Author Information
Author(s): Bautista Jocelyn F, Quade Shannon RE, Parrado Antonio R, Goddard Katrina AB
Primary Institution: Case Western Reserve University
Hypothesis
What is the relationship between alcoholism, P300 amplitude, and habitual smoking?
Conclusion
The study found separate genetic determinants for the effects of alcoholism and smoking status on P300 amplitude.
Supporting Evidence
- Linkage analysis showed significant evidence for alcoholism on chromosome 10.
- P300 amplitude as a covariate provided additional evidence of linkage to chromosome 12.
- Evidence of linkage for P300 phenotype was found on chromosome 7 in non-smokers.
- Linkage to chromosome 17 was observed in alcoholics.
Takeaway
Scientists looked at how drinking and smoking affect brain waves called P300. They found different genes for each behavior.
Methodology
Model-free linkage analysis using SNP and microsatellite markers on the COGA dataset.
Potential Biases
Potential bias due to the exclusion of diverse populations.
Limitations
The study was limited to predominantly White, non-Hispanic families, which may affect generalizability.
Participant Demographics
1253 White, non-Hispanic individuals, including 633 men and 620 women.
Statistical Information
P-Value
2.0 × 10-5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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