Direct Measurement of Perchlorate Exposure Biomarkers in a Highly Exposed Population: A Pilot Study
2011

Measuring Perchlorate Exposure in a Community

Sample size: 31 publication 10 minutes Evidence: moderate

Author Information

Author(s): Paul English, Ben Blount, Michelle Wong, Lori Copan, Luis Olmedo, Sharyle Patton, Robert Haas, Ryan Atencio, Juhua Xu, Liza Valentin-Blasini

Primary Institution: California Environmental Health Tracking Program, California Department of Public Health

Hypothesis

What are the levels of perchlorate exposure among individuals consuming locally grown produce in the Imperial Valley?

Conclusion

The study found that residents of the Imperial Valley had higher perchlorate exposure levels compared to national reference ranges, with some individuals exceeding acceptable daily doses.

Supporting Evidence

  • Perchlorate exposure is widespread in the U.S. population.
  • Participants had higher perchlorate doses compared to national reference ranges.
  • Three participants exceeded the acceptable daily dose as defined by California health standards.

Takeaway

This study looked at how much perchlorate people in a certain area were exposed to from their food and water, and found that some people had more than what is considered safe.

Methodology

The study collected 24-hour urine samples from participants and measured urinary excretion rates of perchlorate, thiocyanate, nitrate, and iodide, along with sampling drinking water and local produce.

Potential Biases

Potential bias due to the convenience sampling method used for participant recruitment.

Limitations

The small sample size and single sampling day limit the generalizability of the results.

Participant Demographics

Participants were primarily Hispanic adults aged 18 to 88, with a significant portion having low educational attainment.

Statistical Information

P-Value

0.04

Confidence Interval

0.08–0.15

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0017015

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