Precancerous Stem Cells Can Serve As Tumor Vasculogenic Progenitors
2008
Precancerous Stem Cells as Tumor Vasculogenic Progenitors
Sample size: 10
publication
10 minutes
Evidence: high
Author Information
Author(s): Shen Rulong, Ye Yin, Chen Li, Yan Qingtao, Barsky Sanford H., Gao Jian-Xin
Primary Institution: Ohio State University
Hypothesis
Do precancerous stem cells serve as progenitors for tumor vasculogenesis?
Conclusion
The study concludes that precancerous stem cells can differentiate into endothelial-like cells and contribute to tumor vasculogenesis.
Supporting Evidence
- Most blood vessels in tumors derived from precancerous stem cells.
- Precancerous stem cells expressed vasculogenic receptor VEGFR-2.
- Precancerous stem cells were more potent in tumor vasculogenesis than differentiated tumor monocytic cells.
Takeaway
This study shows that some early cancer cells can help form blood vessels in tumors, which is important for the tumor to grow.
Methodology
The researchers transplanted precancerous stem cells into SCID mice and analyzed the resulting tumors for blood vessel formation.
Participant Demographics
SCID mice were used for the experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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