Preliminary Phytochemical Screening and Antispasmodic Activity of Artemisia macrocephala Jacquem
2011
Antispasmodic Effects of Artemisia macrocephala
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Niaz Ali, Shah SWA, Shah I
Primary Institution: Institute of Basic Medical Sciences, Khyber Medical University
Hypothesis
Does Artemisia macrocephala exhibit antispasmodic activity through calcium channel blockade?
Conclusion
Artemisia macrocephala has antispasmodic action through calcium channel blocking, supporting its traditional use.
Supporting Evidence
- A. macrocephala caused relaxation of spontaneous rabbits’ jejunum preparations at a dose of 10.0 mg/mL.
- The extract produced a rightward shift in calcium chloride curves, indicating calcium channel blockade.
- Phytochemical screening showed the presence of flavonoids, saponins, glycosides, alkaloids, and terpenes.
Takeaway
This study found that a plant called Artemisia macrocephala can help relax muscles in the stomach by blocking certain channels that let calcium in.
Methodology
The study involved testing the methanolic extract of A. macrocephala on rabbit jejunum preparations to assess its relaxant effects.
Participant Demographics
Rabbits of either sex were used in the experiments.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI: 6.2 to 7.5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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