The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides

2008

APOA5 Trp19 allele and metabolic syndrome

Sample size: 3138 publication Evidence: moderate

Author Information

Author(s): Dallongeville Jean, Cottel Dominique, Wagner Aline, Ducimetière Pierre, Ruidavets Jean-Bernard, Arveiler Dominique, Bingham Annie, Ferrières Jean, Amouyel Philippe, Meirhaeghe Aline

Primary Institution: Institut Pasteur de Lille

Hypothesis

The study aims to assess the effect of genetic variability at the APOA5/A4/C3/A1 cluster locus on the risk of metabolic syndrome.

Conclusion

The APOA5 Trp19 allele increased susceptibility to metabolic syndrome via its impact on plasma triglyceride levels.

Supporting Evidence

The APOA5 Trp19 allele was associated with an increased risk of metabolic syndrome.
Adjustment for triglycerides abolished the associations between APOA5 or APOA4 SNPs and the risk of metabolic syndrome.
APOA5 -12,238C and APOA4 Ser347 alleles were associated with a lower risk of metabolic syndrome.

Takeaway

This study found that a specific gene variant can make people more likely to have metabolic syndrome, which is linked to high fat levels in the blood.

Methodology

The study analyzed genetic polymorphisms in a representative population sample of 3138 individuals, including those with and without metabolic syndrome.