FGF21 Regulation by Fasting and Feeding Signals
Author Information
Author(s): Uebanso Takashi, Taketani Yutaka, Yamamoto Hironori, Amo Kikuko, Ominami Hirokazu, Arai Hidekazu, Takei Yuichiro, Masuda Masashi, Tanimura Ayako, Harada Nagakatsu, Yamanaka-Okumura Hisami, Takeda Eiji
Primary Institution: Department of Clinical Nutrition, Institute of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan
Hypothesis
How is the human FGF21 gene regulated by fasting and feeding signals?
Conclusion
Human FGF21 gene expression is regulated by both fasting and feeding signals, indicating its role in nutritional adaptation.
Supporting Evidence
- FGF21 is induced in the liver by fasting and regulates glucose and lipid metabolism.
- Glucose and xylitol can independently induce human FGF21 gene transcription.
- ChREBP is necessary for glucose-induced FGF21 gene expression.
Takeaway
FGF21 is a hormone that helps control how our body uses sugar and fat, and it can be turned on by both not eating and eating.
Methodology
The study involved deletion analysis of the human FGF21 promoter and experiments with glucose and xylitol in cell cultures.
Limitations
The study primarily used cell lines and may not fully represent in vivo conditions.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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