LPS Disrupts Endometrial Receptivity in Sheep
Author Information
Author(s): Fan Xing, Wei Jinzi, Guo Yu, Ma Juan, Qi Meiyu, Huang He, Zheng Peng, Jiang Wenjie, Yao Yuchang, Vaiman Daniel
Primary Institution: Northeast Agricultural University, Harbin, China
Hypothesis
LPS infusion during early pregnancy damages the receptive endometrium of sheep and negatively affects embryo implantation.
Conclusion
LPS infusion impairs endometrial receptivity in sheep by inhibiting the JAK2/STAT1 signaling pathway, affecting embryo implantation.
Supporting Evidence
- LPS infusion significantly decreased the phosphorylation level of STAT1.
- LPS treatment altered the expression of key implantation genes in sheep.
- The PGE2/PGF2α ratio significantly decreased after LPS infusion.
- Endometrial receptivity-related genes were downregulated by LPS infusion.
- LPS infusion impaired endometrial receptivity through the JAK2/STAT1 pathway.
Takeaway
When sheep are given a substance from bacteria, it makes it harder for them to get pregnant because it messes up the part of their body that helps babies attach.
Methodology
The study involved LPS infusion in sheep at three critical periods of pregnancy and analysis of endometrial gene expression and signaling pathways.
Limitations
The in vivo environment is complex and in vitro simulation may not fully replicate the real situation.
Participant Demographics
Healthy and undelivered 12-month-old ewes with normal estrous cycles.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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