Probiotic Ligilactobacillus salivarius NCUH062003 Reduces Helicobacter pylori Infection in Mice
Author Information
Author(s): Li Junyi, Xu Xiaoyan, Yang Shiyu, Liu Kui, Wu Min, Xie Mingyong, Xiong Tao
Primary Institution: Nanchang University
Hypothesis
Can Ligilactobacillus salivarius NCUH062003 effectively inhibit Helicobacter pylori infection and its associated gastric damage in mice?
Conclusion
Ligilactobacillus salivarius NCUH062003 effectively reduces Helicobacter pylori colonization and mitigates gastric inflammation and damage in mice.
Supporting Evidence
- L. salivarius NCUH062003 significantly reduced H. pylori colonization rates in the gastric mucosa of mice.
- The probiotic decreased levels of pro-inflammatory cytokines and improved gastric mucosal integrity.
- NCUH062003 enhanced gut microbiota diversity and composition in H. pylori-infected mice.
- The combination of NCUH062003 with antibiotics showed a greater reduction in H. pylori colonization compared to antibiotics alone.
- Probiotic treatment improved the overall health of the gastric mucosa in mice.
Takeaway
This study shows that a probiotic called Ligilactobacillus salivarius NCUH062003 can help fight off a bad bacteria called Helicobacter pylori that can make you sick.
Methodology
The study involved 10-week animal experiments with C57BL/6 mice, where the effects of L. salivarius NCUH062003 on H. pylori infection were assessed through various biochemical and histological analyses.
Potential Biases
Potential bias in the selection of probiotic strains and the interpretation of results.
Limitations
The study was conducted only in mice, and results may not directly translate to humans.
Participant Demographics
C57BL/6 mice, aged 4-6 weeks.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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