Fosfomycin Resistance in Cattle Bacteria in Japan
Author Information
Author(s): Hosoi Yuta, Kawanishi Michiko, Harada Saki, Kumakawa Mio, Matsuda Mari, Sekiguchi Hideto, Tagliavia Marcello, Saavedra Lucila
Primary Institution: Veterinary AMR Center, National Veterinary Assay Laboratory, Ministry of Agriculture, Forestry and Fisheries, Tokyo, Japan
Hypothesis
What are the fosfomycin resistance rates and underlying mechanisms in Escherichia coli and Salmonella spp. among cattle in Japan?
Conclusion
The study found low fosfomycin resistance rates in E. coli and Salmonella spp. from cattle in Japan.
Supporting Evidence
- Fosfomycin resistance rates were found to be 0.3% in healthy cattle E. coli.
- Resistance rates were 6.8% in diseased cattle E. coli and 1.4% in Salmonella spp.
- FosA3 gene was detected in most fosfomycin-resistant strains.
- Whole-genome sequencing revealed multiple mechanisms of resistance.
Takeaway
Scientists checked how many bacteria in cows could resist a medicine called fosfomycin, and they found that very few could resist it.
Methodology
Susceptibility tests and whole-genome sequencing were performed on bacteria samples from healthy and diseased cattle.
Limitations
The study only covers specific years and may not represent all regions or conditions in Japan.
Participant Demographics
Samples were taken from healthy (n=292) and diseased (n=73) cattle across various years.
Statistical Information
P-Value
0.39
Confidence Interval
[0–1.9%]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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