Antimicrobial Effects of Ganoderma lucidum Extracts
Author Information
Author(s): Ewunkem Akamu, Merrills Lydia, Williams Zahirah, Justice Brittany, Iloghalu Uchenna, Williams Vera, Singh Dinesh
Primary Institution: Winston Salem State University
Hypothesis
The study aims to investigate the antimicrobial potential of ethanolic, aqueous, and dual solvent extracts of Ganoderma lucidum against resistant bacterial pathogens.
Conclusion
The extracts of Ganoderma lucidum exhibit antimicrobial activity against Staphylococcus aureus and Escherichia coli, causing morphological changes and mutations in genes.
Supporting Evidence
- All extracts of Ganoderma lucidum showed varying degrees of antimicrobial effects against Staphylococcus aureus and Escherichia coli.
- The ethanolic extract exhibited the most potent antimicrobial activity.
- Scanning electron microscopy revealed significant morphological changes in bacterial cells after treatment with the extracts.
- Genomic analysis identified mutations in genes associated with growth and stress response in treated bacteria.
Takeaway
This study shows that extracts from a type of mushroom can help fight off bad bacteria that make us sick.
Methodology
The study used broth dilution methods to test the antimicrobial effects of different solvent extracts against specific bacteria and employed genomic analysis to observe mutations.
Limitations
The study did not specify the exact sample size or the range of concentrations tested for the extracts.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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