Prognosis of Invasive Lobular Carcinomas of the Breast
Author Information
Author(s): R.S. du Toit, A.P. Locker, I.O. Ellis, C.W. Elston, R.I. Nicholson, R.W. Blamey
Primary Institution: City Hospital, Nottingham
Hypothesis
This study investigates the clinical behavior and prognosis of different histopathological subtypes of invasive lobular carcinoma.
Conclusion
The tubulo-lobular subtype of invasive lobular carcinoma has the best prognosis, while the solid subtype has the worst.
Supporting Evidence
- The tubulo-lobular subtype had a 12-year survival rate of 100%.
- The solid subtype had a 12-year survival rate of only 47%.
- The tubulo-lobular group recurred significantly less frequently than the other subtypes.
- Patients with the solid variant should be closely monitored for local recurrences.
Takeaway
Doctors looked at different types of breast cancer to see how they behave and how well patients do. They found that one type is much better than the others.
Methodology
The study reviewed histological sections of invasive lobular carcinomas treated over an 11-year period and analyzed survival and disease-free intervals among different subtypes.
Potential Biases
Grading may be biased as tubule formation is only seen in the tubulo-lobular subtype.
Limitations
The small number of cases in some subtypes made it difficult to investigate them properly for prognosis.
Participant Demographics
The median age of participants was 54 years, with a range from 27 to 78 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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