Dental Care for Kids with Bleeding Disorders
Author Information
Author(s): Sanja Vujkov, Branislav Bajkin, Duška Blagojević, Isidora Nešković, Jelena Komšić, Ana Tadić, Bojan Petrović
Primary Institution: Faculty of Medicine, University of Novi Sad, Serbia
Hypothesis
This systematic review evaluates the effectiveness of various hematological treatment protocols and local hemostatic measures in preventing oral bleeding and other complications during and after dental treatments in children with inherited bleeding disorders and inhibitors.
Conclusion
The review highlights the need for standardized protocols that integrate new prophylactic treatments such as Emicizumab to reduce bleeding complications during dental procedures.
Supporting Evidence
- Emicizumab has significantly shifted the treatment paradigm for children with inherited bleeding disorders and inhibitors.
- The prophylactic use of Emicizumab has been associated with a marked reduction in the frequency of bleeding episodes.
- Fewer hospital admissions for bleeding management were reported among patients treated with Emicizumab.
- Enhanced participation in daily activities was noted in children receiving Emicizumab treatment.
Takeaway
This study looks at how to help kids with bleeding disorders have safer dental treatments. It found that using new medicines can help stop bleeding better.
Methodology
The study was a systematic review that included a comprehensive search across five databases for relevant literature published from January 2000 to February 2024.
Potential Biases
Potential selection and reporting biases were identified, which may affect the interpretation of the findings.
Limitations
The review faced limitations such as a small number of studies, limited diversity in study populations, and potential publication bias.
Participant Demographics
The studies included 13 pediatric patients, with 11 diagnosed with severe hemophilia A and 2 with type 3 von Willebrand disease, all having inhibitors.
Digital Object Identifier (DOI)
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