Mismatch Repair Deficiency in Advanced Solid Tumors in Mexico
Author Information
Author(s): Dorantes-Heredia Rita, Motola-Kuba Daniel, Escamilla-López Ixel, Téllez-Bernal Eduardo, Conde-Flores Emilio, Escalera-Santamaría Daniel, Medina-Ceballos Emilio, Ruiz-Morales José, Dorokhova Elena, Flores-García Lucia Edith, Lugo Gabriela, Filio-Rodríguez Georgina del C.
Primary Institution: Médica Sur, Mexico City
Hypothesis
This study aimed to determine the prevalence of deficient mismatch repair (dMMR) in colorectal and selected non-colorectal solid tumors.
Conclusion
The study found that dMMR prevalence was 12.7% for colorectal cancer, 8.3% for gastric cancer, and 18.5% for endometrial cancer.
Supporting Evidence
- 12.7% of colorectal cancer cases were found to have dMMR.
- 8.3% of gastric cancer cases exhibited dMMR.
- 18.5% of endometrial cancer cases showed dMMR.
- 100% of esophageal cancers were proficient in mismatch repair.
- The highest prevalence of dMMR was found in the 41-50 age group at 20%.
- Prevalence rates were similar across genders, with 11.1% in women and 12.9% in men.
Takeaway
This study looked at how often a certain type of cancer has problems fixing its DNA, which can help doctors know how to treat it better.
Methodology
This retrospective study analyzed patient records from a private health institution in Mexico City, focusing on colorectal, gastric, esophageal, and endometrial cancers diagnosed between January 2017 and December 2020.
Potential Biases
Potential biases due to preanalytical issues with tissue samples and lack of standardization in molecular techniques.
Limitations
The study is descriptive and non-randomized, limiting the ability to draw causal conclusions, and may not represent the entire Mexican population.
Participant Demographics
The study included both male and female patients with colorectal, gastric, esophageal, and endometrial cancers, with a notable prevalence of dMMR in men compared to women.
Digital Object Identifier (DOI)
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