Mannitol Challenge for Chronic Cough Assessment
Author Information
Author(s): Amisha Singapuri, Susan McKenna, Christopher E Brightling
Primary Institution: Institute of Lung Health, University of Leicester
Hypothesis
Subjects with non-asthmatic chronic cough have a heightened cough in response to mannitol.
Conclusion
The mannitol challenge may have potential as a novel cough challenge test, but further research is needed.
Supporting Evidence
- The mannitol challenge showed heightened cough sensitivity in chronic cough subjects compared to controls.
- The study found a reasonable repeatability for the mannitol challenge over one week.
- Mannitol C2 and C5 had a sensitivity of 69% and 62%, respectively, to distinguish chronic coughers from healthy controls.
Takeaway
This study looked at how a test using mannitol can help understand chronic cough, and found it might be useful but needs more testing.
Methodology
The study involved a mannitol challenge test on 16 healthy controls and 13 subjects with chronic cough, assessing cough severity and health status.
Potential Biases
Potential bias due to small sample size and recruitment from specific clinics.
Limitations
The study was a pilot with a small sample size, limiting the ability to generalize findings.
Participant Demographics
16 healthy controls and 13 subjects with chronic cough, with a mean age of 54 for chronic coughers.
Statistical Information
P-Value
0.04
Confidence Interval
[95% CI 0.54–0.91]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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