Model-based cardiovascular monitoring during endotoxic shock in pigs
Author Information
Author(s): Revie JA, Stevenson DJ, Chase JG, Hann CE, Shaw GM, Le Compte A, Lambermont BC, Ghuysen A, Kolh P, Desaive T
Primary Institution: University of Canterbury, Christchurch, New Zealand
Hypothesis
The research aims to test the ability of a model-based method to track disease-dependent hemodynamic changes in sepsis.
Conclusion
Subject-specific cardiovascular models can accurately capture acute hemodynamic changes due to endotoxic shock in pigs using minimal measurements.
Supporting Evidence
- The model predicted left and right ventricular volumes and pressures with mean absolute errors of 7.1% and 6.7%.
- Changes in modelled right ventricular metrics compared well with experimental data.
- Systemic vascular resistance decreased initially in all pigs and stabilized below baseline during hemofiltration.
- Hyperdynamic states were observed in two pigs, affecting mean arterial pressure and cardiac output.
Takeaway
The study shows that special models can help doctors understand how a pig's heart and blood vessels react during a serious infection.
Methodology
Hemodynamic measurements were recorded every 30 minutes in four trials of 4 hours with a porcine model of septic shock.
Participant Demographics
Porcine model (pigs)
Digital Object Identifier (DOI)
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