High Prevalence of High-Risk HPV Among People with and Without HIV: Insights into Risk Factors for Tailored Screening Approaches

2024

High Prevalence of High-Risk HPV Among MSM with and Without HIV

Sample size: 1577 publication Evidence: high

Author Information

Author(s): Bruzzesi Elena, Gandini Federica, Diotallevi Sara, Lolatto Riccardo, Cernuschi Massimo, Candela Caterina, Raccagni Angelo Roberto, Passini Flavia, Tamburini Andrea Marco, Burioni Roberto, Castagna Antonella, Nozza Silvia, Ciccozzi Massimo, Pujol Flor Helene, Branda Francesco

Primary Institution: Infectious Diseases Unit, Vita-Salute San Raffaele University, Milan, Italy

Hypothesis

The study aimed to assess the prevalence of anal HPV among MSM with HIV and without HIV, and to investigate associated risk factors.

Conclusion

The study found a high prevalence of high-risk HPV among MSM, particularly those with concurrent STIs, suggesting a need for tailored screening approaches.

Supporting Evidence

87.6% of participants tested positive for at least one high-risk HPV.
MWoH were significantly younger than MWH.
Cytological abnormalities were more frequent among younger MSM.
High-grade lesions were more frequent among those over 35 years of age.
Concomitant STIs were associated with higher risk of HR-HPV.
93.5% of MSM had at least one HPV serotype detected.
HPV prevalence was higher in MSM with HIV compared to those without.

Takeaway

This study shows that many young men who have sex with men are likely to have a virus that can cause cancer, especially if they have other infections.