THR0921, a novel peroxisome proliferator-activated receptor gamma agonist, reduces the severity of collagen-induced arthritis
2005
THR0921 Reduces Arthritis Severity in Mice
Sample size: 10
publication
Evidence: moderate
Author Information
Author(s): Tomita Tetsuya, Kakiuchi Yoshimi, Tsao Philip S
Primary Institution: Stanford University School of Medicine
Hypothesis
THR0921 may have protective effects in a murine model of rheumatoid arthritis.
Conclusion
THR0921 attenuates collagen-induced arthritis by reducing the immune response.
Supporting Evidence
- THR0921 significantly reduced clinical disease activity scores in treated mice.
- Histological scores of joint destruction were significantly lower in THR0921-treated mice.
- Proliferation of isolated spleen cells was decreased by THR0921 treatment.
Takeaway
Researchers found that a new drug called THR0921 helps mice with arthritis feel better by calming down their immune system.
Methodology
DBA/1J mice were treated with THR0921 after inducing collagen-induced arthritis and assessed for clinical and histological scores.
Limitations
The prophylactic study design limits immediate clinical translation.
Participant Demographics
Female DBA/1J mice, six weeks old.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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