Link Between High Uric Acid Levels and Kidney Disease in Japanese Men
Author Information
Author(s): Kawashima Masatoshi, Wada Koji, Ohta Hiroshi, Terawaki Hiroyuki, Aizawa Yoshiharu
Primary Institution: Kitasato University School of Medicine
Hypothesis
Asymptomatic hyperuricemia may be associated with new-onset chronic kidney disease.
Conclusion
Asymptomatic hyperuricemia is a predictive factor for new-onset chronic kidney disease in Japanese male workers.
Supporting Evidence
- 100 participants developed new-onset CKD during the follow-up period.
- The hazard ratio for new-onset CKD in participants with hyperuricemia was 3.99.
- The study followed participants for a mean of 95.2 months.
Takeaway
This study found that having high uric acid levels without symptoms can lead to kidney problems in men who work in factories.
Methodology
A retrospective cohort study followed male factory workers over 40 years old for up to 18 years, analyzing health data from annual examinations.
Limitations
Participants with a history of gouty attacks were excluded, and treatment for hyperuricemia was not considered.
Participant Demographics
All participants were male factory workers over 40 years of age.
Statistical Information
P-Value
< 0.01
Confidence Interval
2.59-6.15
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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