Sedation with Dexmedetomidine and Midazolam by Non-Anesthesiologists
Author Information
Author(s): Ishido Kenji, Tanabe Satoshi, Kitahara Gen, Furue Yasuaki, Wada Takuya, Watanabe Akinori, Matsuda Hiromi, Okamoto Hirotsugu, Kusano Chika
Primary Institution: Kitasato University School of Medicine
Hypothesis
The efficacy and safety of a sedation regimen combining dexmedetomidine and midazolam during endoscopic submucosal dissection for upper gastrointestinal tumors remains unclear.
Conclusion
A sedation regimen combining dexmedetomidine and midazolam can be feasibly administered by non-anesthesiologists.
Supporting Evidence
- All endoscopic submucosal dissection procedures were completed successfully.
- 44.1% of patients experienced hypotension, and 44.1% experienced bradycardia.
- 1.5% of patients had peripheral arterial oxygen saturation below 90%.
Takeaway
Doctors who aren't anesthesiologists can safely give patients sedation using a mix of two medicines during certain stomach procedures.
Methodology
The study retrospectively evaluated 68 patients who underwent endoscopic submucosal dissection for upper gastrointestinal tumors, sedated by non-anesthesiologists under supervision.
Potential Biases
Selection bias may exist due to the clinical practice perspective.
Limitations
The study was a single-center, retrospective, observational study without randomized controlled trials.
Participant Demographics
Median age was 74 years for superficial esophageal cancer and 75 years for early gastric cancer and gastric adenoma; 13 males and 1 female for superficial esophageal cancer, and 43 males and 11 females for early gastric cancer and gastric adenoma.
Statistical Information
P-Value
0.012
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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