Muscle Mass Measurement and Liver Disease
Author Information
Author(s): Tatsuta Miwa, Masaki Tsutomu, Kimura Shungo, Sato Yudai, Tomida Akemi, Ishikawa Ichiro, Nakamura Yu, Takuma Kei, Nakahara Mai, Oura Kyoko, Tadokoro Tomoko, Fujita Koji, Tani Joji, Morishita Asahiro, Himoto Takashi, Miyazaki Shinjiro, Maeta Tsuyoshi, Mori Yoshihiro, Kohi Fumikazu, Kobara Hideki, Puppa Melissa
Primary Institution: KKR Takamatsu Hospital
Hypothesis
This study aimed to identify significant body composition factors associated with metabolic dysfunction-associated steatotic liver disease (MASLD) in patients undergoing health checkups.
Conclusion
Skeletal muscle mass/weight (SMM/WT) was significantly associated with MASLD, suggesting it may serve as a potential marker for diagnosis.
Supporting Evidence
- 3864 examinees were enrolled in the study.
- 1133 males and 454 females were diagnosed with MASLD.
- SMM/WT was independently associated with MASLD.
- The prevalence of sarcopenia was very low among examinees with MASLD.
- Muscle mass assessment using SMM/WT may improve diagnosis of MASLD.
Takeaway
This study found that measuring muscle mass can help doctors figure out if someone has a liver disease called MASLD.
Methodology
The study analyzed data from 6599 examinees who underwent health checkups, focusing on body composition and its association with MASLD.
Potential Biases
Differences in age, gender, and ethnic background may affect the body composition components.
Limitations
The study was conducted at a single center, which may limit the generalizability of the findings.
Participant Demographics
The study included 2188 males and 1676 females, with a mean age around 54 years.
Statistical Information
P-Value
p<0.0001
Confidence Interval
95% CI: 2.99–8.73 for males, 95% CI: 1.68–6.93 for females
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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