Histamine H3 Receptors in Rat Aorta
Author Information
Author(s): D. M. Djuric, I. Z. Andjelkovic
Primary Institution: Institute of Physiology, Medical Faculty University of Belgrade
Hypothesis
Are histamine H3 receptors present on rat aorta endothelium and what is their role in endothelium-dependent responses?
Conclusion
The study found a heterogeneous population of histamine receptors, H1 and H3, on rat aorta endothelium that may participate in endothelium-dependent responses to histamine.
Supporting Evidence
- Histamine induced a concentration-dependent relaxation of rat aorta.
- The presence of endothelium was essential for the relaxing effect of histamine.
- Pyrilamine and thioperamide shifted the concentration-response curve for histamine to the right.
- Removal of the endothelium abolished relaxation to histamine.
- Histamine H3 receptors were found to inhibit neurotransmission in the peripheral nervous system.
Takeaway
This study looked at how histamine affects blood vessels in rats and found that certain receptors help control this process.
Methodology
The study involved isolating rat aorta segments and testing their relaxation response to histamine and (R)-MeHA in the presence of various antagonists.
Participant Demographics
Male Wistar rats weighing between 100 and 200g
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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