The role of ADAM33 gene in childhood asthma
Author Information
Author(s): Schedel Michaela, Depner Martin, Schoen Carola, Weiland Stephan K, Vogelberg Christian, Niggemann Bodo, Lau Susanne, Illig Thomas, Klopp Norman, Wahn Ulrich, von Mutius Erika, Nickel Renate, Kabesch Michael
Primary Institution: University Children's Hospital, Ludwig Maximilian's University Munich, Germany
Hypothesis
Is the ADAM33 gene associated with childhood asthma, lung function, and bronchial hyperresponsiveness?
Conclusion
The study could not confirm the previously reported association between ADAM33 polymorphisms and asthma, but suggests a complex role in non-atopic asthma.
Supporting Evidence
- No single SNP showed a significant association with doctor's diagnosis of asthma.
- A trend for more profound effects of ADAM33 SNPs was observed in individuals with asthma and bronchial hyperresponsiveness.
- Haplotype analyses suggested a minor effect of the ADAM33 haplotype H4 on asthma.
- Associations with non-atopic asthma and baseline lung function were identified.
Takeaway
Scientists studied a gene called ADAM33 to see if it affects asthma in kids, but they found it might not be as important as they thought.
Methodology
Genotyping of ten ADAM33 SNPs in 1,872 children from ISAAC II and 824 children from the MAS cohort.
Limitations
The study could not detect significant associations for many SNPs and the role of environmental factors was not established.
Participant Demographics
Children from two German populations, including asthmatics and non-asthmatics.
Statistical Information
P-Value
0.033
Confidence Interval
95%CI 1.01–2.31
Statistical Significance
p = 0.033
Digital Object Identifier (DOI)
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