Impact of dopamine deficiency and REM sleep behavior disorder on cognition in early neuronal synuclein disease
Author Information
Author(s): Weintraub Daniel, Nair Anuprita R, Kurth Ryan, Brumm Michael C., York Michele K., Dobkin Roseanne, Marek Kenneth, Tanner Caroline, Simuni Tanya, Siderowf Andrew, Galasko Douglas, Chahine Lana M., Coffey Christopher, Merchant Kalpana, Poston Kathleen L., Foroud Tatiana, Mollenhauer Brit, Brown Ethan G., Kieburtz Karl, Frasier Mark, Sherer Todd, Chowdhury Sohini, Alcalay Roy N., Videnovic Aleksandar
Primary Institution: the Parkinson’s Progression Markers Initiative
Hypothesis
The study aims to determine the impact of dopamine deficiency and isolated REM sleep behavior disorder on cognitive performance in early neuronal alpha-synuclein disease with hyposmia.
Conclusion
Early neuronal synuclein disease with hyposmia is linked to cognitive deficits, especially when dopamine system impairment or comorbid REM sleep behavior disorder is present.
Supporting Evidence
- Stage 2A participants with hyposmia alone had normal cognition.
- Stage 2B participants with hyposmia had abnormal cognition.
- Comorbid REM sleep behavior disorder was associated with significantly worse cognition in Stage 2A.
Takeaway
This study found that people with early signs of a brain disease related to dopamine and sleep issues may have trouble thinking clearly.
Methodology
Cognitive performance was assessed using a cognitive summary score based on baseline data from the Parkinson’s Progression Markers Initiative.
Participant Demographics
Participants included individuals classified as Stage 2A and Stage 2B of neuronal synuclein disease, along with healthy controls.
Statistical Information
P-Value
0.0078
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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