(±)-(1SR,5SR,6SR,7SR,10SR,11SR,13RS,14SR,15SR,16RS)-13-acetoxy-16-benzyloxy-15-hydroxy-7-methoxymethoxy-3-oxo-11,15,18,18-tetramethyl-2,4-dioxatetracyclo[12.3.1.01,5.06,11]octadecan-10-yl benzoate and its 13-epimer
2025
Crystal Structures of Tetracyclic Benzoates Related to Paclitaxel
publication
Evidence: high
Author Information
Author(s): Oishi Takeshi, Fukaya Keisuke, Sato Takaaki, Chida Noritaka
Primary Institution: Keio University
Conclusion
The study describes the crystal structures of two tetracyclic benzoates, revealing similarities in their ring conformations and the presence of hydrogen bonds that form inversion dimers.
Supporting Evidence
- The crystal structures of the compounds were analyzed and compared.
- Both compounds exhibited similar ring conformations.
- Hydrogen bonds were identified that link the molecules into dimers.
Takeaway
Scientists looked at the shapes of two similar molecules made from a plant medicine called Paclitaxel. They found that even though the molecules are a bit different, they stick together in similar ways.
Methodology
The crystal structures were determined using X-ray diffraction techniques.
Digital Object Identifier (DOI)
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