Impact of 14-3-3 sigma on vulvar squamous cell carcinomas
Author Information
Author(s): Wang Zhihui, Tropè Claes G, Suo Zhenhe, Trøen Gunhild, Yang Guanrui, Nesland Jahn M, Holm Ruth
Primary Institution: The Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
Hypothesis
The study investigates the role of 14-3-3 sigma protein expression in the pathogenesis and prognosis of vulvar squamous cell carcinomas.
Conclusion
14-3-3 sigma may be involved in the development of some vulvar squamous cell carcinomas, but its expression is not associated with prognosis.
Supporting Evidence
- High levels of 14-3-3 sigma were found in 72% of vulvar carcinomas.
- High expression of 14-3-3 sigma was significantly correlated with larger tumor diameter.
- 14-3-3 sigma expression was not associated with disease-specific survival.
Takeaway
This study looked at a protein called 14-3-3 sigma in vulvar cancer and found that while it might help the cancer grow, it doesn't help doctors predict how well a patient will do.
Methodology
The study used immunohistochemistry to analyze 14-3-3 sigma expression in 302 vulvar squamous cell carcinoma samples and correlated it with clinicopathological factors.
Limitations
The study did not find a significant association between 14-3-3 sigma expression and disease-specific survival.
Participant Demographics
The median age at diagnosis was 74 years, with a range from 35 to 96 years.
Statistical Information
P-Value
p = 0.001, p = 0.002, p = 0.01, p = 0.007
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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