Comparative genomics of Clostridium perfringens bacteriophages
Author Information
Author(s): Brian B. Oakley, Eldin Talundzic, Cesar A. Morales, Kelli L. Hiett, Gregory R. Siragusa, Nikolay V. Volozhantsev, Bruce S. Seal
Primary Institution: Poultry Microbiological Research Unit, Richard B. Russell Agricultural Research Center, Agricultural Research Service, USDA
Hypothesis
Understanding the genomic context of bacteriophage gene products is essential for their biotechnological applications.
Conclusion
Significant genomic diversity exists among closely-related bacteriophages, with implications for their use in biotechnology.
Supporting Evidence
- Phage genomes showed close relationships to each other and to other Clostridial phages.
- Endolysins and holins are conserved functions across divergent phage genomes.
- Significant variability was found in endolysin sequences among closely-related phages.
Takeaway
Scientists studied four similar viruses that attack bacteria to see how they are different and how they can be used to fight infections.
Methodology
The genomes of four bacteriophages were sequenced and analyzed for evolutionary relationships and genomic context.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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