RasGrf1 and Aging
2011
RasGrf1 and Aging
Editorial
Evidence: moderate
Author Information
Author(s): Davies Kelvin J. A., Forman Henry Jay
Primary Institution: Ethel Percy Andrus Gerontology Center of the Davis School of Gerontology, the University of Southern California
Hypothesis
Does the deletion of RasGrf1 affect aging and longevity in mice?
Conclusion
The deletion of RasGrf1 increases longevity and reduces frailty in mice.
Supporting Evidence
- The complete elimination of RasGrf1 increased both average and maximal longevity independent of a role in cancer.
- RasGrf1 deletion is associated with lower frailty and better motor control.
- RasGrf1-/- mice showed approximately 25% lower levels of malondialdehyde compared to wild-type mice.
- Old RasGrf1 deletion mutants had almost 30% lower levels of oxidized liver proteins than young wild-type mice.
Takeaway
Mice without a gene called RasGrf1 live longer and are healthier, even though this gene is usually important for normal body functions.
Limitations
The measure of lipid peroxidation may be subject to artifacts.
Statistical Information
Statistical Significance
p<0.05
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