Impact of Perilipin Polymorphisms on Obesity and Diabetes in French Population
Author Information
Author(s): Aline Meirhaeghe, Séverine Thomas, Frédéric Ancot, Dominique Cottel, Dominique Arveiler, Jean Ferrières, Philippe Amouyel
Primary Institution: INSERM, U744, Lille; Institut Pasteur de Lille, Lille; Université de Lille 2, Lille, France
Hypothesis
Are perilipin gene polymorphisms associated with obesity and type 2 diabetes in a French population?
Conclusion
The perilipin gene polymorphisms rs4578621 and rs894160 are not major genetic determinants of obesity and type 2 diabetes-related phenotypes in the studied population.
Supporting Evidence
- Only two perilipin polymorphisms were frequent enough to study in detail.
- No significant associations were found between the polymorphisms and obesity or diabetes-related phenotypes.
- The study included a large sample size of 1120 individuals.
Takeaway
This study looked at whether certain gene changes related to a protein called perilipin affect obesity and diabetes in French people, and found that they do not.
Methodology
Cross-sectional study with genotyping of perilipin polymorphisms in a random sample of French adults aged 35 to 65.
Limitations
The study may not have sufficient power to detect small associations and only focused on two specific SNPs.
Participant Demographics
1120 French men and women aged 35 to 65, including 227 obese and 275 type 2 diabetes subjects.
Statistical Information
P-Value
0.04
Statistical Significance
p = 0.04
Digital Object Identifier (DOI)
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