Memantine for Migraine Prevention: A Review
Author Information
Author(s): Li Guanglu, Qu Baoquan, Zheng Tao, Duan Shaojie, Liu Lei, Liu Zunjing
Primary Institution: Beijing University of Chinese Medicine, Beijing, China
Hypothesis
Is memantine effective in reducing migraine frequency compared to other preventive medications?
Conclusion
Memantine significantly reduces migraine frequency and improves response rates, showing comparable effectiveness to current preventive treatments.
Supporting Evidence
- Memantine showed the second-largest reduction in migraine days compared to placebo.
- Memantine had the highest 50% response rates among all studied interventions.
- Memantine demonstrated the lowest dropout rate and moderate frequency of adverse events.
Takeaway
Memantine can help people with migraines by reducing how often they happen and how bad they are, making it a good option for treatment.
Methodology
A systematic review and network meta-analysis of randomized controlled trials comparing memantine with other migraine preventive medications.
Potential Biases
Some concerns about the risk of bias in the included studies.
Limitations
Limited number of studies on memantine and small sample sizes may affect the reliability of the findings.
Participant Demographics
Adult migraine patients, with studies conducted in various countries including India, Mexico, and Iran.
Statistical Information
P-Value
0.05
Confidence Interval
95% CI: −1.26, −0.41
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website