DRUG DEVELOPMENT AND EVALUATION: AGE, SEX, AND FRAILTY CONSIDERATIONS TO FACILITATE THE FORTITUDE FACTOR
2024
Drug Development for Older Adults
publication
Author Information
Author(s): Hilmer Sarah
Primary Institution: Royal North Shore Hospital, Sydney, Australia
Hypothesis
How do age, sex, and frailty affect drug development and evaluation in older adults?
Conclusion
Drug development for older adults must consider various factors like age, sex, and frailty to ensure effective outcomes.
Supporting Evidence
- Age, sex, and frailty can significantly affect drug clearance and sensitivity.
- Polypharmacy and multimorbidity complicate drug effect predictions in older adults.
- The IUPHAR Geriatric Committee emphasizes the importance of frailty measurement in drug development.
Takeaway
When making medicine for older people, we need to think about how their age, gender, and health can change how the medicine works.
Methodology
The study discusses principles for drug development and evaluation relevant to older adults, including the measurement of frailty and the use of modeling.
Participant Demographics
Older adults, considering factors like age, sex, and frailty.
Digital Object Identifier (DOI)
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