Prognostic Values of PCNA and Ki-67 in Oesophageal Cancer Treatment
Author Information
Author(s): Okuno Y, Nishimura Y, Kashu I, Ono K, Hiraoka M
Primary Institution: Department of Radiology, Faculty of Medicine, Kyoto University
Hypothesis
The study investigates the relationship between PCNA and Ki-67 indices and local control and survival rates in oesophageal squamous cell carcinoma patients treated with radiotherapy.
Conclusion
PCNA and Ki-67 indices are significantly correlated with local control probabilities in oesophageal squamous cell carcinomas treated by definitive radiotherapy.
Supporting Evidence
- Patients with PCNA LI < 52% or Ki-67 LI < 45% had significantly higher local recurrence rates.
- PCNA LI was independent of known prognostic factors for local control.
Takeaway
Doctors looked at two markers in cancer cells to see if they could predict how well patients would do after treatment. They found that these markers can help tell which patients might have more problems after treatment.
Methodology
The study analyzed biopsy materials from patients before radiotherapy and assessed the PCNA and Ki-67 labelling indices in relation to local control and survival rates.
Participant Demographics
Patients with oesophageal squamous cell carcinoma treated by definitive radiotherapy.
Statistical Information
P-Value
P = 0.0056 for T-stage; P = 0.0332 for PCNA LI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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