A Case of Aquagenic Syringeal Acrokeratoderma in a Male Patient Undergoing Treatment With an Angiotensin-Converting Enzyme Inhibitor
2024

Case of Aquagenic Syringeal Acrokeratoderma in a Male Patient

Sample size: 1 publication Evidence: low

Author Information

Author(s): Muacevic Alexander, Adler John R, Lindsay Justin, Incristi Aurelia R, Arnett Bryson, Costa Marcelo, Chong Christian

Primary Institution: Wright State Boonshoft School of Medicine, Dayton, USA

Hypothesis

The use of an angiotensin-converting enzyme (ACE) inhibitor may contribute to the onset of aquagenic syringeal acrokeratoderma symptoms.

Conclusion

This case highlights a rare presentation of aquagenic syringeal acrokeratoderma in a young male patient without cystic fibrosis, potentially linked to ACE inhibitor use.

Supporting Evidence

  • Aquagenic syringeal acrokeratoderma is characterized by transient papules on the palms after water exposure.
  • The patient experienced symptoms for 10 months, worsening over time.
  • The condition is often associated with cystic fibrosis but can occur in patients without it.

Takeaway

A man developed a rare skin condition that makes his hands react to water, possibly because of a medication he was taking.

Methodology

The diagnosis was clinical, based on the patient's symptoms and history, without the need for biopsy or water immersion tests.

Limitations

The case is based on a single patient, limiting generalizability.

Participant Demographics

24-year-old male patient without a history of cystic fibrosis.

Digital Object Identifier (DOI)

10.7759/cureus.74157

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