Stability of Inflammatory Biomarkers After Stroke
Author Information
Author(s): Mitchell S. V. Elkind, Kristen Coates, Wanling Tai, Myunghee C. Paik, Bernadette Boden-Albala, Ralph L. Sacco
Primary Institution: Columbia University, New York, NY, USA
Hypothesis
The study aims to determine the stability of levels of inflammatory biomarkers after ischemic stroke.
Conclusion
Levels of hsCRP are higher in stroke patients than in stroke-free subjects, and these levels remain stable for at least 28 days after the first ischemic stroke.
Supporting Evidence
- Levels of hsCRP were significantly higher in stroke patients compared to stroke-free participants.
- No significant time trend was observed in levels of hsCRP, SAA, or fibrinogen during the 28 days of follow-up.
- The study included a diverse, multi-ethnic population of stroke patients.
Takeaway
After a stroke, certain proteins in the blood that indicate inflammation stay at the same level for about a month, and people who have had a stroke have higher levels of these proteins than those who haven't.
Methodology
Plasma levels of hsCRP, SAA, and fibrinogen were measured at seven time points after stroke in patients aged 40 and older.
Potential Biases
Limited power to detect changes over time and between subgroups due to small sample size.
Limitations
The study had a small sample size and did not measure protein levels beyond 28 days.
Participant Demographics
Mean age was 65.6 years, 61.9% were male, and 71.4% were Hispanic.
Statistical Information
P-Value
0.0252
Statistical Significance
p = 0.0252
Digital Object Identifier (DOI)
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