HPV Type Concordance and Condom Use in Sexual Couples
Author Information
Author(s): Bleeker M C G, Berkhof J, Hogewoning C J A, Voorhorst F J, van den Brule A J C, Starink T M, Snijders P J F, Meijer C J L M
Primary Institution: VU University Medical Center
Hypothesis
Does the effect of condom use on the regression of flat penile lesions depend on the presence of HPV type concordance in sexual couples?
Conclusion
Condom use effectively blocks HPV transmission and promotes regression of flat penile lesions in men whose female partners have the same HPV type.
Supporting Evidence
- Condom use was associated with a hazard ratio of 2.63 for regression of flat penile lesions in concordant couples.
- Delayed regression of lesions was linked to reinfection from the female partner.
- HPV type concordance was found in 57 couples, with 32 in the condom group.
Takeaway
Using condoms can help men with flat penile lesions get better if their partner has the same type of HPV.
Methodology
The study used a randomized clinical trial design with a Cox model to analyze the effect of condom use on the regression of flat penile lesions in relation to HPV type concordance.
Potential Biases
Recall bias regarding condom use may affect the results, although it is unlikely to significantly influence the data.
Limitations
Potential underestimation of concordant couples due to false negatives in penile scrapes and recall bias regarding condom use.
Participant Demographics
The study included 118 men with flat penile lesions, with a mean age of 38.7 years.
Statistical Information
P-Value
0.035
Confidence Interval
95% CI 1.07–6.48
Statistical Significance
p=0.035
Digital Object Identifier (DOI)
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