CYP Gene Variants and Colorectal Cancer Risk
Author Information
Author(s): Bethke Lara, Webb Emily, Sellick Gabrielle, Rudd Matthew, Penegar Stephen, Withey Laura, Qureshi Mobshra, Houlston Richard
Primary Institution: Institute of Cancer Research, Surrey, UK
Hypothesis
Do common variants of CYP genes influence colorectal cancer risk?
Conclusion
This study provides some support for polymorphic variation in CYP1A2 and CYP1B1 playing a role in CRC susceptibility.
Supporting Evidence
- CYP1B1 rs162558 homozygotes showed increased CRC risk.
- CYP1A2 rs2069522 heterozygotes were also associated with increased CRC risk.
- The study had a large sample size compared to previous studies.
Takeaway
Some genes that help break down chemicals in our body might affect how likely someone is to get colon cancer.
Methodology
The study genotyped 2,575 colorectal cancer cases and 2,707 controls for 20 SNPs in various CYP genes.
Limitations
The associations found were not significant after correction for multiple testing.
Participant Demographics
Patients included 1,474 males and 1,101 females, all British Caucasians.
Statistical Information
P-Value
p=1.0 (adjusted)
Confidence Interval
95% CI: 1.03–1.80 for CYP1B1 rs162558; 95% CI: 1.00–1.79 for CYP1A2 rs2069522
Digital Object Identifier (DOI)
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