Meiosis specific coiled-coil proteins in Shizosaccharomyces pombe
2007

Meiosis-Specific Coiled-Coil Proteins in Fission Yeast

publication Evidence: moderate

Author Information

Author(s): Ayami Ohtaka, Takamune Saito, Daisuke Okuzaki, Hiroshi Nojima

Primary Institution: Department of Molecular Genetics, Research Institute for Microbial Diseases, Osaka University

Hypothesis

The coiled-coil motifs in meiosis-specific proteins play essential roles in meiotic progression.

Conclusion

Coiled-coil motifs are crucial for the function of several meiosis-specific proteins in Schizosaccharomyces pombe.

Supporting Evidence

  • Coiled-coil motifs are essential for meiotic progression in Schizosaccharomyces pombe.
  • Meu13 and Mcp7 form a complex that is crucial for meiotic recombination.
  • Mcp6/Hrs1 is required for proper astral microtubule positioning during meiosis.
  • Mcp5/Num1 regulates horsetail chromosome movement by anchoring dynein.

Takeaway

Some proteins in yeast that help with making eggs and sperm have special shapes that help them do their jobs during cell division.

Methodology

The study reviews recent findings on meiotic coiled-coil proteins in Schizosaccharomyces pombe.

Limitations

The roles of coiled-coil motifs in many meiosis-specific proteins remain unclear.

Digital Object Identifier (DOI)

10.1186/1747-1028-2-14

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