Loss of DCC gene expression during ovarian tumorigenesis: relation to tumour differentiation and progression
2000
Loss of DCC Gene Expression in Ovarian Tumors
Sample size: 124
publication
Evidence: moderate
Author Information
Author(s): Saegusa M, Machida D, Okayasu I
Primary Institution: Kitasato University School of Medicine
Hypothesis
What is the role of DCC gene alteration in ovarian neoplasias?
Conclusion
Impaired DCC expression may play an important role in ovarian tumorigenesis and is linked with tumor differentiation and progression.
Supporting Evidence
- DCC expression was significantly lower in carcinomas compared to benign and low malignant potential lesions.
- Reduction of DCC expression was significantly related to the serous phenotype and high histological grade.
- No association was noted between DCC score values and survival.
Takeaway
The study found that a gene called DCC is less active in ovarian tumors compared to benign conditions, which might help explain how these tumors develop.
Methodology
The study used immunohistochemistry and RT-PCR/SBH to analyze DCC mRNA levels in various ovarian samples.
Participant Demographics
Included 124 carcinomas, 55 cystadenomas, and 41 low malignant potential tumors.
Statistical Information
P-Value
P< 0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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