Butyrate regulates E-cadherin transcription, isoform expression and intracellular position in colon cancer cells
2000
Butyrate and E-cadherin in Colon Cancer Cells
publication
Author Information
Author(s): Barshishat M, Polak-Charcon S, Schwartz B
Primary Institution: Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem
Hypothesis
Butyrate regulates cell-adhesion proteins in colon cancer cells.
Conclusion
Butyrate treatment enhances cell-to-cell interaction and E-cadherin expression in colon cancer cells.
Supporting Evidence
- Butyrate treatment enhanced cell-to-cell interaction in colon cancer cells.
- E-cadherin expression was increased following butyrate treatment.
- The study compared two types of colon cancer cells with different mucin production.
Takeaway
Butyrate helps colon cancer cells stick together better and increases a protein called E-cadherin that helps with this sticking.
Methodology
The study examined the effects of butyrate on cell-adhesion proteins in two types of human colon cancer cells.
Digital Object Identifier (DOI)
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