3-(4-Chloroanilino)-2,5-dimethylcyclohex-2-en-1-one
2011
Study of 3-(4-Chlorophenylamino)-2,5-dimethylcyclohex-2-enone
Sample size: 6
publication
Evidence: moderate
Author Information
Author(s): Henry North, Wutoh Kwame, Odoom M’egya K., Karla Pradeep, Scott Kenneth R., Butcher Ray J.
Primary Institution: Howard University
Hypothesis
The title compound possesses significant anticonvulsant properties.
Conclusion
The compound showed protective effects against tonic-clonic convulsions in mice at certain doses.
Supporting Evidence
- The compound was exclusively active in the maximal electroshock seizure evaluation in mice.
- At a dose of 100 mg kg-1, all tested animals were protected at 30 minutes.
- At a dose of 300 mg kg-1, one animal was protected at both 30 minutes and 4 hours.
Takeaway
This study looked at a new chemical that might help stop seizures in people. It worked well in mice when given in the right amount.
Methodology
The study involved testing the compound's effects on seizure activity in mice and rats using the maximal electroshock seizure evaluation.
Limitations
The study had a small sample size and some animals showed toxicity at higher doses.
Participant Demographics
Mice and rats were used in the study.
Digital Object Identifier (DOI)
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